Ansu Perekatt

Assistant Professor

School: School of Engineering and Science

Department: Chemistry and Chemical Biology

Building: McLean Hall

Room: 212

Phone: (201) 216-3759

Email: aperekat@stevens.edu

Website

Research

Cancers often relapse: why? My lab is interested in understanding how tumor-initiating cells persist in intestinal cancers. The research focus is on the molecular mechanisms underlying cell-fate plasticity, which allows colon tumor cells to switch their fate to colon cancer stem cells that are responsible for the colon tumor growth. To investigate the mechanism that allows cell fate plasticity, and thus the persistence of colon cancer stem cells, we are using a mutant mouse model that display cell fate-plasticity and tumor initiation. Our research is expected to inform novel therapeutic strategies targeting tumor relapse.

We use a combination of vivo mouse models and ex vivo intestinal organoid cultures to answer our research questions using various molecular biology techniques.

Institutional Service
  • CCB Graduate Curriculum Committee Member
  • Biology Lecturer Search Committee Member
  • CCB Graduate Student Admissions committee Member
  • Information for CCB external academic unit review Member
Honors and Awards

Gallow Award for Outstanding Cancer Research from The Cancer Institute of New Jersey and the New Jersey Commission on Cancer Research (NJCCR) in years 2014, 2016, and 2018

Professional Societies
  • AACR – American Association for Cancer Research Member
  • CINJ – Cancer Institute of New Jersey Member
  • NYAS – New York Academy of Sciences Senior member
  • NYAS – New York Academy of Sciences Member
Grants, Contracts, and Funds

K22 Career Transition Award from NCI/NIH: $486,000
(September 2018 to Spetember 2022)

Selected Publications
Journal Article
  1. Li, C.; Shah, J.; Wrath, K.; Mills, C.; Perekatt, A. (2021). 3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation. Journal of Visual Experiments (JoVE) . 2021 Apr 1;(170). doi: 10.3791/61809. (2021 Apr 1;(170) ed.).
    https://www.jove.com/t/61809/3d-culturing-organoids-from-intestinal-villi-epithelium-undergoing.
  2. Chen, L.; Toke, N. H.; Luo, S.; Vasoya, R. P.; Fullem, R. L.; Parthasarathy, A.; Perekatt, A.; Verzi, M. P. (2019). A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity.. Nature genetics (5 ed., vol. 51, pp. 777-785).
  3. Ma, X.; Das, N. K.; Castillo, C.; Gourani, A.; Perekatt, A.; Verzi, M. P.; Shah, Y. M. (2019). SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes.. The Journal of biological chemistry (11 ed., vol. 294, pp. 3974-3986).
  4. Perekatt, A.; Shah, P. P.; Cheung, S.; Jariwala, N.; Wu, A.; Gandhi, V.; Kumar, N.; Feng, Q.; Patel, N.; Chen, L.; Joshi, S.; Zhou, A.; Taketo, M. M.; Xing, J.; White, E.; Gao, N.; Gatza, M. L.; Verzi, M. P. (2018). SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium.. Cancer research (17 ed., vol. 78, pp. 4878-4890).
Courses

BIO281 Biology and Biotechnology