Cancers often relapse: why? My lab is interested in understanding how tumor-initiating cells persist in intestinal cancers. The research focus is on the molecular mechanisms underlying cell-fate plasticity, which allows colon tumor cells to switch their fate to colon cancer stem cells that are responsible for the colon tumor growth. To investigate the mechanism that allows cell fate plasticity, and thus the persistence of colon cancer stem cells, we are using a mutant mouse model that display cell fate-plasticity and tumor initiation. Our research is expected to inform novel therapeutic strategies targeting tumor relapse.
We use a combination of vivo mouse models and ex vivo intestinal organoid cultures to answer our research questions using various molecular biology techniques.
- Core instrument facility committee Member
- committee on animal facility expansion Chair
Gallow Award for Outstanding Cancer Research from The Cancer Institute of New Jersey and the New Jersey Commission on Cancer Research (NJCCR) in years 2014, 2016, and 2018
- AACR – American Association for Cancer Research Member
- CINJ – Cancer Institute of New Jersey Member
- NYAS – New York Academy of Sciences Senior member
- NYAS – New York Academy of Sciences Member
K22 Career Transition Award from NCI/NIH: $486,000
(September 2018 to Spetember 2022)
- Li, C.; Shah, J.; Wrath, K.; Mills, C.; Perekatt, A. (2021). 3D Culturing of Organoids from the Intestinal Villi Epithelium Undergoing Dedifferentiation. Journal of Visual Experiments (JoVE) . 2021 Apr 1;(170). doi: 10.3791/61809. (2021 Apr 1;(170) ed.).
- Chen, L.; Toke, N. H.; Luo, S.; Vasoya, R. P.; Fullem, R. L.; Parthasarathy, A.; Perekatt, A.; Verzi, M. P. (2019). A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity.. Nature genetics (5 ed., vol. 51, pp. 777-785).
- Ma, X.; Das, N. K.; Castillo, C.; Gourani, A.; Perekatt, A.; Verzi, M. P.; Shah, Y. M. (2019). SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes.. The Journal of biological chemistry (11 ed., vol. 294, pp. 3974-3986).
- Perekatt, A.; Shah, P. P.; Cheung, S.; Jariwala, N.; Wu, A.; Gandhi, V.; Kumar, N.; Feng, Q.; Patel, N.; Chen, L.; Joshi, S.; Zhou, A.; Taketo, M. M.; Xing, J.; White, E.; Gao, N.; Gatza, M. L.; Verzi, M. P. (2018). SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium.. Cancer research (17 ed., vol. 78, pp. 4878-4890).
Biology and Biotechnology