Brunella Taddeo

Lecturer

School: School of Engineering and Science

Department: Chemistry and Chemical Biology

Building: McLean Hall

Room: 201

Phone: (201) 216-8082

Email: btaddeo@stevens.edu

Education
  • PhD (1994) “La Sapienza” University (Microbiology & Epidemiology)
  • BS (1987) “La Sapienza” University (Biological Sciences)
General Information

Dr. Brunella Taddeo obtained a B.S. in Biological Science and a Ph.D. in Microbiology & Epidemiology from “La Sapienza” University in Rome, Italy. Her post-doctoral fellowship at the Dana Farber Cancer Institute in Boston focused on the role of HIV-1 integrase in the viral replication, working under the supervision of Dr. W. Haseltine and Dr. J. Sodroski. She then expanded her interests in virology by first working on the HIV-1 and HHV-8 interactions at The Loyola University Medical center (Maywood, IL) and, after joining the Prof. B. Roizman’s team at The University of Chicago, focusing her research on the ability of Herpes Simplex Virus 1 to shut off the host cellular replication machinery. Her work led to more than 36 peer-reviewed publications. After relocating in NYC area in 2012, she pursued transferring her deep biological knowledge in educational settings by providing basic and advanced courses in Biology, Genetic, Microbiology etc. at various NYC area institutions including Mercy College, New York City College of Technology and Hostos Community College, before joining Stevens Institute of Technology as biology Lecturer in the department of Chemistry and Chemical Biology, at Charles V. Schaefer, Jr. School of Engineering & Science.

Institutional Service
  • CCB Department: Tenure stream faculty search committee Member
  • CCB Department: Undergraduate Education Committee Member
Professional Societies
  • ASM – American Society of Microbiology Member
Selected Publications
Book Chapter
  1. Roizman, B.; Taddeo, B.; Arvin, A.; Campadelli-Fiume, G.; Mocarski, E.; Moore, P. S.; Roizman, B.; Whitley, R.; Yamanishi, K. (2007). The strategy of herpes simplex virus replication and takeover of the host cell. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge University Press.
  2. Taddeo, B. (2006). HSV-1 and the Host Cell: A Story of Global Conspiracies, Plots and Counterplots. Alpha Herpesviruses: Molecular and Cellular Biology, 1st ed.. Caister Academic Press.
Journal Article
  1. Shu, M.; Taddeo, B.; Roizman, B. (2015). Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage.. Journal of virology (10 ed., vol. 89, pp. 5643-50).
  2. Shu, M.; Taddeo, B.; Roizman, B. (2013). The nuclear-cytoplasmic shuttling of virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU-rich and stable cellular mRNAs.. Journal of virology (24 ed., vol. 87, pp. 13569-78).
  3. Taddeo, B.; Zhang, W.; Roizman, B. (2013). The herpes simplex virus host shutoff RNase degrades cellular and viral mRNAs made before infection but not viral mRNA made after infection.. Journal of virology (8 ed., vol. 87, pp. 4516-22).
  4. Sciortino, M. T.; Parisi, T.; Siracusano, G.; Mastino, A.; Taddeo, B.; Roizman, B. (2013). The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1.. Journal of virology (6 ed., vol. 87, pp. 3271-6).
  5. Shu, M.; Taddeo, B.; Zhang, W.; Roizman, B. (2013). Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.. Proceedings of the National Academy of Sciences of the United States of America (18 ed., vol. 110, pp. E1669-75).
  6. Sgadari, C.; Barillari, G.; Palladino, C.; Bellino, S.; Taddeo, B.; Toschi, E.; Ensoli, B. (2011). Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma.. International journal of vascular medicine (vol. 2011, pp. 452729).
  7. Taddeo, B.; Zhang, W.; Roizman, B. (2010). Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase.. Journal of virology (19 ed., vol. 84, pp. 10182-90).
  8. Taddeo, B.; Zhang, W.; Roizman, B. (2009). The virion-packaged endoribonuclease of herpes simplex virus 1 cleaves mRNA in polyribosomes.. Proceedings of the National Academy of Sciences of the United States of America (29 ed., vol. 106, pp. 12139-44).
  9. Taddeo, B.; Sciortino, M. T.; Zhang, W.; Roizman, B. (2007). Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA.. Proceedings of the National Academy of Sciences of the United States of America (29 ed., vol. 104, pp. 12163-8).
  10. Sciortino, M. T.; Taddeo, B.; Giuffrè-Cuculletto, M.; Medici, M. A.; Mastino, A.; Roizman, B. (2007). Replication-competent herpes simplex virus 1 isolates selected from cells transfected with a bacterial artificial chromosome DNA lacking only the UL49 gene vary with respect to the defect in the UL41 gene encoding host shutoff RNase.. Journal of virology (20 ed., vol. 81, pp. 10924-32).
  11. Taddeo, B.; Roizman, B. (2006). The virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A.. Journal of virology (18 ed., vol. 80, pp. 9341-5).
  12. Taddeo, B.; Zhang, W.; Roizman, B. (2006). The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins.. Proceedings of the National Academy of Sciences of the United States of America (8 ed., vol. 103, pp. 2827-32).
  13. Esclatine, A.; Taddeo, B.; Roizman, B. (2004). The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs.. Proceedings of the National Academy of Sciences of the United States of America (52 ed., vol. 101, pp. 18165-70).
  14. Taddeo, B.; Zhang, W.; Lakeman, F.; Roizman, B. (2004). Cells lacking NF-kappaB or in which NF-kappaB is not activated vary with respect to ability to sustain herpes simplex virus 1 replication and are not susceptible to apoptosis induced by a replication-incompetent mutant virus.. Journal of virology (21 ed., vol. 78, pp. 11615-21).
  15. Taddeo, B.; Esclatine, A.; Roizman, B. (2004). Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells.. Biochemical Society transactions (Pt 5 ed., vol. 32, pp. 697-701).
  16. Esclatine, A.; Taddeo, B.; Roizman, B. (2004). Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs.. Journal of virology (16 ed., vol. 78, pp. 8582-92).
  17. Esclatine, A.; Taddeo, B.; Evans, L.; Roizman, B. (2004). The herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific.. Proceedings of the National Academy of Sciences of the United States of America (10 ed., vol. 101, pp. 3603-8).
  18. Taddeo, B.; Luo, T. R.; Zhang, W.; Roizman, B. (2003). Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis.. Proceedings of the National Academy of Sciences of the United States of America (21 ed., vol. 100, pp. 12408-13).
  19. Taddeo, B.; Esclatine, A.; Zhang, W.; Roizman, B. (2003). The stress-inducible immediate-early responsive gene IEX-1 is activated in cells infected with herpes simplex virus 1, but several viral mechanisms, including 3' degradation of its RNA, preclude expression of the gene.. Journal of virology (11 ed., vol. 77, pp. 6178-87).
  20. Taddeo, B.; Esclatine, A.; Roizman, B. (2002). The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene.. Proceedings of the National Academy of Sciences of the United States of America (26 ed., vol. 99, pp. 17031-6).
  21. Sciortino, M. T.; Taddeo, B.; Poon, A. P.; Mastino, A.; Roizman, B. (2002). Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection.. Proceedings of the National Academy of Sciences of the United States of America (12 ed., vol. 99, pp. 8318-23).
  22. Sciortino, M. T.; Suzuki, M.; Taddeo, B.; Roizman, B. (2001). RNAs extracted from herpes simplex virus 1 virions: apparent selectivity of viral but not cellular RNAs packaged in virions.. Journal of virology (17 ed., vol. 75, pp. 8105-16).
  23. Kang, Y.; Taddeo, B.; Varai, G.; Varga, J.; Fiore, S. (2000). Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling.. Biochemistry (44 ed., vol. 39, pp. 13551-7).
  24. Mercader, M.; Taddeo, B.; Panella, J. R.; Chandran, B.; Nickoloff, B. J.; Foreman, K. E. (2000). Induction of HHV-8 lytic cycle replication by inflammatory cytokines produced by HIV-1-infected T cells.. The American journal of pathology (6 ed., vol. 156, pp. 1961-71).
  25. Sodin-Semrl, S.; Taddeo, B.; Tseng, D.; Varga, J.; Fiore, S. (2000). Lipoxin A4 inhibits IL-1 beta-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases.. Journal of immunology (Baltimore, Md. : 1950) (5 ed., vol. 164, pp. 2660-6).
  26. Taddeo, B.; Nickoloff, B. J.; Foreman, K. E. (2000). Caspase inhibitor blocks human immunodeficiency virus 1-induced T-cell death without enhancement of HIV-1 replication and dimethyl sulfoxide increases HIV-1 replication without influencing T-cell survival.. Archives of pathology & laboratory medicine (2 ed., vol. 124, pp. 240-5).
  27. Ward, P. L.; Taddeo, B.; Markovitz, N. S.; Roizman, B. (2000). Identification of a novel expressed open reading frame situated between genes U(L)20 and U(L)21 of the herpes simplex virus 1 genome.. Virology (2 ed., vol. 266, pp. 275-85).
  28. Taddeo, B.; Carlini, F.; Verani, P.; Engelman, A. (1996). Reversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivity.. Journal of virology (12 ed., vol. 70, pp. 8277-84).
  29. Parolin, C.; Taddeo, B.; Palú, G.; Sodroski, J. (1996). Use of cis- and trans-acting viral regulatory sequences to improve expression of human immunodeficiency virus vectors in human lymphocytes.. Virology (2 ed., vol. 222, pp. 415-22).
  30. Taddeo, B.; Haseltine, W. A.; Farnet, C. M. (1994). Integrase mutants of human immunodeficiency virus type 1 with a specific defect in integration.. Journal of virology (12 ed., vol. 68, pp. 8401-5).
  31. Shin, C. G.; Taddeo, B.; Haseltine, W. A.; Farnet, C. M. (1994). Genetic analysis of the human immunodeficiency virus type 1 integrase protein.. Journal of virology (3 ed., vol. 68, pp. 1633-42).
Courses

BIO281 Biology & Biotechnology
BIO381 Cell Biology
BIO392 Microbiology
BIO484 Molecular Genetics