Marcin Iwanicki

Assistant Professor

School: School of Engineering and Science

Department: Chemistry and Chemical Biology

Building: McLean Hall

Room: 316

Phone: (201) 216-8193

Fax: (201) 216-8315

Email: miwanick@stevens.edu

Website

Education
  • PhD (2008) University of Virginia (Microbiology/Cancer Biology and Immunology )
Research

Mechanisms of ovarian cancer metastatic progression in the context of recovery from chemotherapeutic treatment.

Our goal is to understand ovarian cancer, so we fear less for our loved ones and ourselves.

General Information

We use a combination of cancer tissue engineering, micro-fabrication, state-of-the-art microscopy and CRISPR/CAS9 gene editing to gain mechanistic insights into ovarian cancer metastasis.

Experience

Marcin’s doctoral studies, supported by NIH Training Grant, were focused on the development of live light-emitting probes and microscopy technologies to study cell migration. During post-doctoral training, supported by NCI Training Grant and philanthropy, at Harvard Medical School in the laboratory of Dr. Joan Brugge, Marcin accumulated in-depth knowledge of cancer biology and 3D culture systems. Specifically, through the collaborations with ovarian cancer physician-scientist at Brigham and Women Hospital, Dana-Farber Cancer Institute, and Massachusetts General Hospital, Marcin has successfully integrated 3D models of ovarian cancer with high-resolution live-cell imaging. Through the development of these methodologies, he has discovered the phenomenon of ovarian cancer mesothelial clearance and its dependence on mutant p53 and mesenchymal transcriptional programs. These studies have underscored the importance of the application of imaging technologies to ovarian cancer research. At Stevens Institute of Technology, our lab has undertaken an integrative approach, based on strengths in 3D tissue culture and microscopy to combine long-term live microscopy with organoid models of ovarian cancer dissemination. These approaches have generated new and exciting opportunities to study ovarian cancer cell populations that detach and disseminate.

Institutional Service
  • CCB Member
  • CCB Department Member
  • SES/Stevens Member
  • Graduate Student Recruitment Chemistry Chemical Biology Member
  • Undergraduate Student Recruitment Member
Professional Service
  • Cancers ( journal) Special Issue Lead Editor
  • NIH/NCI Study Section Member
  • DOD Study Section Member
  • MDPI/Cancers Contributing Editor
  • Cell Press/ Cell Reports Review Editor
  • Oncotarget Review Editor
Honors and Awards

2001-2006 Pre-doctoral, Ruth Kirschstein Award, NCI
2006-2009 Post-doctoral, Cell Migration Consortium, NIH
2009 -2012 Post-doctoral, Ruth Kirschstein Award, NCI
2012-2017 Post-doctoral, Adelson Research Foundation
2015 Post-doctoral, Ovarian Cancer Action HHMT fellowship, United Kingdom
2015 Post-doctoral, The Marsha Rivkin Center for Ovarian Cancer Research Scholar-in-Training Award

Professional Societies
  • ASMB – American Society for Matrix Biology Member
  • Biomedical Engineering Society Member
  • AACR – American Society for Cancer Research Member
Grants, Contracts, and Funds

2020 NCI/NIH: High-Resolution Dynamic Imaging of Ovarian Cancer Metastasis Post Chemotherapy.

2019 Kaleidoscope of Hope Ovarian Cancer Research Foundation: Application of Photoreactive Probes and Fiberoptic Devices for Detection of Fallopian Tube Cell Transformation in Organoid-On-Chip Models of Ovarian Cancer.

2019 OLIPASS.INC: Targeting Taurine Receptor in Therapy Resistant Ovarian Cancer

Selected Publications
Journal Article
  1. Iwanicki, M. (2021). Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma. Moleular Cancer Research . Philadelphia, Pennsylvania : American Association for Cancer Research .
  2. Iwanicki, M. (2020). The Interplay of the Extracellular Matrix and Stromal Cells as a Drug Target in Stroma-Rich Cancers. Trends Pharmacol Sci. (3 ed., vol. 41, pp. 183). Cambridge, Massachusetts : Cell Press.
  3. Farsinejad, S.; Cattabiani, T.; Muranen , T.; Iwanicki, M. (2019). Ovarian Cancer Dissemination-A Cell Biologist’s Perspective. No. Cancers (12 ed., vol. 11, pp. 1957). Basel: MDPI.
  4. Zaborowski, M. (2019). Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. Cell Reports (27(1) ed., pp. 255-268). Cambridge, MA: Cell Press.
    https://www.ncbi.nlm.nih.gov/pubmed/30943406.
Courses

BIO526
BIO381
BIO201